OPA3 Protein Homologues
Homo sapiens
Accession code: NP_001017989.2
The link above is for the protein sequence of the human OPA3 gene.
Accession code: NP_001017989.2
The link above is for the protein sequence of the human OPA3 gene.
Protein sequences are the order and number of amino acids in a protein, in this case OPA3B in the transcript of interest and is comprised of 180 amino acids. The links will show the respective sequences for each species listed.
Homology refers to biological similarities between organisms due to their ancestry and evolutionary origins [1]. The protein sequences below are homologous because they have similar amino acids sequences that have been conserved over evolutionary time from the ancestral OPA3 gene.
Homology refers to biological similarities between organisms due to their ancestry and evolutionary origins [1]. The protein sequences below are homologous because they have similar amino acids sequences that have been conserved over evolutionary time from the ancestral OPA3 gene.
What are model organisms?
Model organisms can be used to study diseases such as optic atrophy and cataract. An ideal model organism has homologous features compared to humans; this allows us to better study the disease. All of the organisms below have a homologous OPA3 gene that is similar to the human gene.
Model organisms can be used to study diseases such as optic atrophy and cataract. An ideal model organism has homologous features compared to humans; this allows us to better study the disease. All of the organisms below have a homologous OPA3 gene that is similar to the human gene.
Model Organisms
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Danio rerioAccession code: NP_001073635.1
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Drosophila melanogasterAccession code: NP_651192.1
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Xenopus laevis
Accession code: NP_001087952.1
Accession code: NP_001087952.1
What model organism is best for OPA3 and ADOA?
OPA3 has homologs in many more organisms, see the phylogeny page for more examples. The model organisms above all have the potential to be used in research for ADOA. However, Danio rerio (Zebrafish), are especially useful in this case as they have a relatively complex eye, similar OPA3 protein domains, and are a popular choice for eye related diseases for genetic modeling. In addition, studying Zebrafish is a quicker and more inexpensive method compared to mice models.
This web page was produced as an assignment for Genetics 564, a capstone course at UW-Madison.
References
[1] Britannica, T. Editors of Encyclopaedia (2024, March 22). homology. Encyclopedia Britannica. https://www.britannica.com/science/homology-evolution
Phylogeny
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